Fremstilling af dobbelt supramolekylær EGCG-carboxymethylchitosan: struktur, antioxidant og antiinflammatoriske egenskaber

In the field of cosmetics, epigallocatechin gallate (EGCG) is highly valued for its multiple effects such as delaying photoaging, whitening, anti-allergy, acne removal, astringency, and moisturizing. However, due to the active chemical properties of EGCG, there are challenges in terms of stability and transdermal absorption, which limits its widespread application in cosmetics. Therefore, school of Pharmacy, Guangzhou Huali College utilized supramolecular modification technology to form supramolecular carboxymethyl chitosan-EGCG-trehalose (CC-EGCG) by combining EGCG with carboxymethyl chitosan and trehalose, enhancing its stability. Then, we Indkapslede den supramolekylære CC-EGCG med hydroxypropylcyclodextrin for at opnå en dobbelt supramolekylær CC-EGCG, som ikke kun forbedrede stabiliteten af råmaterialet og reducerede dets irritation til huden, men også forbedret huden permeabilitet (sammenlignet med enkelt EGCG, dobbeltprøven, dobbeltprøven tider) . biotilgængeligheden af EGCG blev markant forbedret, hvilket fik det til at spille en bedre rolle i antioxidant, hvidtning, beroligende og fjernelse af oliekontrol acne.